Sample preparation for creams, lotions, gels and ointments is a difficult task. Their high viscosity or unique rheology causes analyte extraction of these sample types to be particularly difficult to disperse. They are most troublesome when the semi-solid base product is not miscible with the preferred solvent required for the assay. This poster will illustrate how automated sample preparation can be utilized to overcome these difficulties. One benefit of automated sample preparation is its ability to eliminate differences in various manual techniques such as sample dispersion.